Mutant p53 refers to a mutated form of the p53 gene, which is a tumor suppressor gene that plays a crucial role in regulating cell growth and preventing the development of cancer. Mutations in the p53 gene can lead to the production of abnormal, dysfunctional p53 proteins that are unable to properly regulate cell growth and division. These mutant p53 proteins can promote tumor formation and progression by allowing cells to ignore signals to stop growing and dividing, leading to uncontrolled cell proliferation and the development of cancer. Research in the area of mutant p53 focuses on understanding the mechanisms by which mutant p53 proteins drive tumorigenesis, as well as exploring potential therapeutic strategies to target mutant p53-positive cancers. Studies have shown that mutant p53 can interact with other cellular proteins and pathways to promote tumor growth, metastasis, and resistance to therapy. Targeting mutant p53 with novel drugs or treatments has the potential to improve outcomes for cancer patients with mutant p53-positive tumors.